Preprints
Tang AS, Wei ML, Haemel A, La C, Sirota M, Lee EY.
Artificial
intelligence-enabled precision medicine for inflammatory skin diseases.
ArXiv [Preprint]. 2025 May 14:arXiv:2505.09527v1. PMID: 40463698; PMCID:
PMC12133082.
Katsuhara Y, Khan U, Miller ZA, Allen IE, Oskotsky TT, Sirota M, Tang AS.
Decoding subphenotypes in
electronic medical records within late-onset Alzheimer's disease reveals
heterogeneity and sex-specific differences.
medRxiv [Preprint]. 2025 Apr 25:2025.04.24.25326306. doi:
10.1101/2025.04.24.25326306. PMID: 40313288; PMCID: PMC12045436.
Breithaupt AG, Weiner M, Tang AS, Possin KL, Sirota M, Lah J, Levey AI,
Hentenryck PV, Zandehshahvar R, Gorno-Tempini ML, Giorgio J, Wang J, Rauschecker AM,
Rosen HJ, Nosheny RL, Miller BL, Pinheiro-Chagas P.
Integrating Generative
Artificial Intelligence in ADRD: A Roadmap for Streamlining Diagnosis and Care
in Neurodegenerative Diseases.
ArXiv [Preprint]. 2025 Feb 6:arXiv:2502.06842v2.
Publications
2025
Li Y, Pereda Serras C, Blumenfeld J, Xie M, Hao Y, Deng E, Chun YY, Holtzman J,
An A, Yoon SY, Tang X, Rao A, Woldemariam S, Tang A, Zhang A, Simms J,
Lo I, Oskotsky T, Keiser MJ, Huang Y, Sirota M.
Cell-type-directed network-correcting combination therapy for Alzheimer's
disease.
Cell 2025 Jul 15:S0092-8674(25)00737-8. doi: 10.1016/j.cell.2025.06.035.
Epub ahead of print. PMID: 40695276.
Tang AS, Brooks L, Boudreau DM, Chanu P, Joshi A, Vora B, Zhu R.
Use of Real-World Claims Data to Assess the Prevalence of Concomitant
Medications to Inform Drug-Drug Interaction Risk in Target Patient
Populations.
Clin Pharmacol Ther. 2025 Jul;118(1):146-155. doi: 10.1002/cpt.3652. Epub
2025 Apr 1. PMID: 40170515.
Zhou M, Tang AS, Zhang H, Xu Z, Ke AMC, Su C, Huang Y, Mantyh WG, Jaffee MS,
Rankin KP, DeKosky ST, Zhou J, Guo Y, Bian J, Sirota M, Wang F.
Identifying Progression
Subphenotypes of Alzheimer's Disease from Large-scale Electronic Health Records
with Machine Learning.
J Biomed Inform. 2025 May;165:104820. doi: 10.1016/j.jbi.2025.104820. Epub
2025 Apr 1. PMID: 40180206.
Kodama L, Woldemariam SR, Tang AS, Li Y, Kornak J, Allen IE, Raphael E,
Oskotsky TT, Sirota M.
Comorbidities associated
with a clinically-recognized delirium diagnosis in the hospital using real
world data.
Commun Med. 2025 Jul 22;5(1):304. doi: 10.1038/s43856-025-00986-5.
PMID: 40696117; PMCID: PMC12284072.
Ramey GD, Tang AS, Phongpreecha T, Yang MM, Woldemariam SR, Oskotsky TT,
Montine TJ, Allen I, Miller ZA, Aghaeepour N, Capra JA, Sirota M.
Exposure to autoimmune
disorders is associated with increased Alzhiemer’s Disease Risk in a Multi-site
Electronic Health Record Analysis.
Cell Rep Med. 2025 Mar 18;6(3):101980. doi: 10.1016/j.xcrm.2025.101980. Epub
2025 Feb 24. PMID: 39999839.
Costello JM, Takasuka H, Roger J, Yin O, Tang AS, Oskotsky T, Sirota M, Capra
JA.
Pre-conception clinical risk
factors differ between spontaneous and indicated preterm birth in a densely
phenotyped EHR cohort.
BMC Pregnancy Childbirth. 2025 Feb 12;25(1):149. doi:
10.1186/s12884-025-07166-2. PMID: 39939846.
2024
Tang AS, Woldemariam SR, Miramontes S, Norgeot B, Oskotsky TT, Sirota M.
Harnessing EHR data for
health research.
Nat Med. 2024 Jul;30(7):1847-1855. doi: 10.1038/s41591-024-03074-8. Epub
2024 Jul 4. PMID: 38965433.
Tang AS, Rankin KP, Cerono G, Miramontes S, Mills H, Roger J, Zeng B, Nelson
C, Soman K, Woldemariam S, Li Y, Lee A, Bove R, Glymour M, Aghaeepour N, Oskotsky
TT, Miller Z, Allen IE, Sanders SJ, Baranzini S, Sirota M.
Leveraging electronic health
records and knowledge networks for Alzheimer's disease prediction and
sex-specific biological insights.
Nat Aging. 2024 Mar;4(3):379-395. doi: 10.1038/s43587-024-00573-8. Epub 2024
Feb 21. PMID: 38383858; PMCID: PMC10950787.
Golob JL, Oskotsky TT, Tang AS, Roldan A, Chung V, Ha CWY, Wong RJ, Flynn KJ,
Parraga-Leo A, Wibrand C, Minot SS, Oskotsky B, Andreoletti G, Kosti I, Bletz J,
Nelson A, Gao J, Wei Z, Chen G, Tang ZZ, Novielli P, Romano D, Pantaleo E, Amoroso
N, Monaco A, Vacca M, De Angelis M, Bellotti R, Tangaro S, Kuntzleman A, Bigcraft I,
Techtmann S, Bae D, Kim E, Jeon J, Joe S; Preterm Birth DREAM Community; Theis KR,
Ng S, Lee YS, Diaz-Gimeno P, Bennett PR, MacIntyre DA, Stolovitzky G, Lynch SV,
Albrecht J, Gomez-Lopez N, Romero R, Stevenson DK, Aghaeepour N, Tarca AL, Costello
JC, Sirota M.
Microbiome preterm birth
DREAM challenge: Crowdsourcing machine learning approaches to advance preterm
birth research.
Cell Rep Med. 2024 Jan 16;5(1):101350. doi: 10.1016/j.xcrm.2023.101350. Epub
2023 Dec 21. PMID: 38134931
2022
Tang AS, Oskotsky T, Havaldar S, Mantyh WG, Bicak M, Solsberg CW, Woldemariam
S, Zeng B, Hu Z, Oskotsky B, Dubal D, Allen IE, Glicksberg BS, Sirota M.
Deep phenotyping of
Alzheimer's disease leveraging electronic medical records identifies
sex-specific clinical associations.
Nat Commun. 2022 Feb 3;13(1):675. doi: 10.1038/s41467-022-28273-0. PMID:
35115528; PMCID: PMC8814236.
